Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27194530 | 0.93 | CRBN (0.60) | CRBNESR1IKZF2 | |
| SCHEMBL30144706 | 0.93 | CRBN (0.60) | CRBNESR1IKZF2 | |
| SCHEMBL27466316 | 0.93 | CRBN (0.55) | CRBNESR1IKZF2 | |
| Hydrochloric Acid SCHEMBL27194374 | 0.92 | CRBN (0.60) | CRBNESR1IKZF2 | |
| Hydrochloric Acid SCHEMBL30828145 | 0.92 | CRBN (0.60) | CRBNESR1IKZF2 | |
| SCHEMBL29614159 | 0.92 | CRBN (0.56) | CRBNESR1IKZF2 | |
| SCHEMBL30821190 | 0.89 | CRBN (0.65) | CRBN | |
| SCHEMBL29614518 | 0.89 | CRBN (0.65) | CRBN | |
| SCHEMBL31726743 | 0.89 | CRBN (0.65) | CRBN | |
| SCHEMBL30821193 | 0.89 | CRBN (0.65) | CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688149-A1 | IRAK4 PROTACS | Astrazeneca AB (SE) | 2026-02-11 | — | — | EP | disclosed |
| US-20240374588-A1 | IRAK4 PROTACS | ASTRAZENECA AB (SE) | 2024-11-14 | — | — | US | disclosed |
| WO-2024209044-A1 | IRAK4 PROTACS | ASTRAZENECA AB (SE) | 2024-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240374588-A1 | IRAK4 PROTACS | IRAK4, IRAK2, IRAK3 | CRBN 99/4885ESR1 879/4885IKZF2 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.