SCHEMBL30144745

SCHEMBL30144745

CC(O)c1ccc2c(Cl)ccnc2c1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
OGA O60502 4/20 0.46
PLG P00747 1/20 0.41
PLAU P00749 1/20 0.41
NR4A2 P43354 2/20 0.41
SMYD3 Q9H7B4 1/20 0.38
SOS2 Q07890 1/20 0.38
TLR8 Q9NR97 1/20 0.38
TAAR1 Q96RJ0 1/20 0.37
UGT2B7 P16662 1/20 0.37
LMNA P02545 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
NTRK1 P04629 1/20 0.34
CYP1A2 P05177 1/20 0.34
MAPT P10636 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17541684 1.00 OGA (0.46) OGAPLGPLAUNR4A2SMYD3
SCHEMBL17541554 0.85 OGA (0.44) OGANR4A2SMYD3SOS2TLR8
SCHEMBL26087032 0.83 OGA (0.42) OGANR4A2SMYD3SOS2TLR8
SCHEMBL23911573 0.83 OGA (0.41) OGANR4A2SMYD3SOS2TLR8
SCHEMBL30133836 0.74 OGA (0.55) OGAPLGPLAUUGT2B7MAPT
SCHEMBL3275241 0.74 OGA (0.55) OGAPLGPLAUUGT2B7MAPT
SCHEMBL27533075 0.73 OGA (0.39) OGANR4A2SMYD3TAAR1LMNA
SCHEMBL23652803 0.73 OGA (0.56) OGA
SCHEMBL29612575 0.73 TLR8 (0.51) NR4A2SMYD3SOS2TLR8LMNA
SCHEMBL30380536 0.73 HTR1A (0.54) NR4A2SMYD3SOS2TLR8LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12187741-B2 Glycosidase inhibitors ASCENEURON SA (CH) 2025-01-07 US disclosed
US-20220411440-A1 GLYCOSIDASE INHIBITORS ASCENEURON SA (CH) 2022-12-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220411440-A1 GLYCOSIDASE INHIBITORS GAA, ENGASE, GBA3 OGA 77/4885PLG 2624/4885PLAU 1582/4885
US-12187741-B2 Glycosidase inhibitors GAA, ENGASE, GBA3 OGA 77/4885PLG 2624/4885PLAU 1582/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.