Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK2 | Q9H0K1 | 14/20 | 0.67 |
| ▸ | SIK3 | Q9Y2K2 | 14/20 | 0.67 |
| ▸ | SIK1 | P57059 | 12/20 | 0.67 |
| ▸ | ABL1 | P00519 | 12/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | KIT | P10721 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 4/20 | 0.57 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | BCR | P11274 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | YES1 | P07947 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31688158 | 0.90 | SIK2 (0.66) | SIK2SIK3SIK1ABL1KDR | |
| SCHEMBL14665835 | 0.89 | ABL1 (0.64) | SIK2SIK3SIK1ABL1KDR | |
| SCHEMBL30144989 | 0.89 | ABL1 (0.75) | SIK2SIK3SIK1ABL1KDR | |
| SCHEMBL3536666 | 0.89 | ABL1 (0.75) | SIK2SIK3SIK1ABL1KDR | |
| SCHEMBL4252892 | 0.89 | ABL1 (0.69) | SIK2SIK3SIK1ABL1KDR | |
| SCHEMBL26455882 | 0.89 | SIK2 (0.64) | SIK2SIK3SIK1ABL1KDR | |
| SCHEMBL19436378 | 0.88 | ABL1 (0.66) | SIK2SIK3SIK1ABL1KDR | |
| SCHEMBL4253276 | 0.88 | LCK (0.66) | SIK2SIK3SIK1ABL1KDR | |
| SCHEMBL31688157 | 0.87 | SIK2 (0.63) | SIK2SIK3SIK1ABL1KDR | |
| SCHEMBL26090180 | 0.87 | SIK2 (0.63) | SIK2SIK3SIK1ABL1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105250-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-04-23 | — | — | US | claimed |
| EP-1841431-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2007-10-10 | — | — | EP | claimed |
| WO-2006081172-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-08-03 | — | — | WO | claimed |
| US-20250296928-A1 | A SYNTHESIS SCHEME AND PROCEDURES FOR PREPARING A SIK3 INHIBITOR AND INTERMEDIATES THEREOF | IOMX THERAPEUTICS AG (DE) | 2025-09-25 | — | — | US | disclosed |
| CN-118369321-A | Synthetic schemes and procedures for preparing SIK3 inhibitors and intermediates thereof | 艾奥麦克斯治疗公司 | 2024-07-19 | — | — | CN | disclosed |
| WO-2023067021-A1 | A SYNTHESIS SCHEME AND PROCEDURES FOR PREPARING A SIK3 INHIBITOR AND INTERMEDIATES THEREOF | IOMX THERAPEUTICS AG (DE) | 2023-04-27 | — | — | WO | disclosed |
| US-20090105250-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-04-23 | — | — | US | disclosed |
| EP-1841431-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006081172-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105250-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | ABL1, BCR, PDGFRB | SIK2 832/4885SIK3 1485/4885SIK1 1137/4885 |
| US-20250296928-A1 | A SYNTHESIS SCHEME AND PROCEDURES FOR PREPARING A SIK3 INHIBITOR AND INTERMEDIATES THEREOF | SIK3, SIK1, SIK2 | SIK2 3/4885SIK3 1/4885SIK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.