Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29202505 | 1.00 | GRIN1 (0.44) | GRIN1KDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL10157245 | 0.85 | HRH4 (0.36) | POLBHCAR2 | |
| SCHEMBL741480 | 0.85 | MAP2K1 (0.49) | RHEBMAPK1 | |
| SCHEMBL740322 | 0.81 | XDH (0.44) | KDM4EHSD17B10ALDH1A1LMNAHPGD | |
| SCHEMBL30882613 | 0.81 | XDH (0.44) | KDM4EHSD17B10ALDH1A1LMNAHPGD | |
| SCHEMBL23147890 | 0.81 | EIF4A3 (0.51) | GRIN1KDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL23147490 | 0.79 | GRIN1 (0.65) | GRIN1KDM4ELMNARHEBHPGD | |
| SCHEMBL29301454 | 0.77 | KDM4E (0.48) | KDM4EHSD17B10ALDH1A1LMNAHPGD | |
| SCHEMBL23147731 | 0.76 | RHEB (0.41) | GRIN1KDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL23147711 | 0.76 | DAO (0.43) | GRIN1KDM4EHSD17B10ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149945-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2023-03-22 | — | — | EP | disclosed |
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |