Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4901026 | 0.87 | MEN1 (0.51) | MAP2K4MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL29301504 | 0.84 | KIF11 (0.42) | MAP2K4MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL29690736 | 0.82 | MEN1 (0.48) | MAP2K4MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL24422909 | 0.81 | MAP2K4 (0.54) | MAP2K4MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL16929779 | 0.80 | JAK2 (0.58) | MAP2K4MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1501529 | 0.80 | KDM4E (0.55) | MAP2K4MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2671105 | 0.80 | MAP2K4 (0.52) | MAP2K4MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2569247 | 0.78 | KDM4E (0.50) | MAP2K4MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9985941 | 0.78 | KDM4E (0.54) | MAP2K4MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL23675227 | 0.78 | MAP2K4 (0.54) | MAP2K4MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149945-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2023-03-22 | — | — | EP | disclosed |
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |