Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495727 | 0.86 | POLB (0.69) | HDAC8HDAC6LMNAPOLBKDM4E | |
| SCHEMBL13151157 | 0.83 | HDAC8 (0.56) | HDAC8HDAC6LMNAPOLBKDM4E | |
| SCHEMBL10294649 | 0.80 | HDAC6 (0.53) | HDAC8HDAC6LMNAPOLBKDM4E | |
| SCHEMBL5909363 | 0.79 | HDAC8 (0.83) | HDAC8HDAC6POLBKDM4ESMN1; SMN2 | |
| SCHEMBL15387056 | 0.79 | PARP1 (0.53) | POLBHSD17B10MAPTMEN1KMT2A | |
| SCHEMBL10154035 | 0.76 | HDAC8 (0.51) | HDAC8HDAC6LMNAPOLBKDM4E | |
| SCHEMBL27736470 | 0.75 | KDM4E (0.56) | HDAC8HDAC6LMNAPOLBKDM4E | |
| SCHEMBL2954975 | 0.75 | HDAC8 (0.65) | HDAC8HDAC6LMNAPOLBKDM4E | |
| SCHEMBL10761520 | 0.74 | HDAC8 (0.69) | HDAC8HDAC6POLBKDM4ESMN1; SMN2 | |
| SCHEMBL14573364 | 0.74 | HDAC8 (0.63) | HDAC8HDAC6POLBKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |