Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.65 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909363 | 0.86 | HDAC8 (0.83) | HDAC8HDAC6SLC7A5PKMPOLB | |
| SCHEMBL7406706 | 0.86 | MEN1 (0.55) | CYP3A4CYP2C9KMT2AMEN1ERN1 | |
| SCHEMBL19704274 | 0.82 | HDAC8 (0.61) | HDAC8HDAC6SLC7A5PKMPOLB | |
| SCHEMBL13701791 | 0.81 | LMNA (0.52) | LMNACYP3A4CYP2C9KMT2AMEN1 | |
| SCHEMBL13702339 | 0.81 | SMN1; SMN2 (0.54) | HDAC8HDAC6POLBCYP3A4KMT2A | |
| SCHEMBL2128427 | 0.80 | HDAC2 (0.59) | HDAC8HDAC6BRD4CYP3A4GAA | |
| SCHEMBL2645114 | 0.79 | ERN1 (0.47) | BRD4CYP3A4KMT2AMEN1ERN1 | |
| SCHEMBL2422043 | 0.79 | HDAC8 (0.71) | HDAC8HDAC6SLC7A5POLBLMNA | |
| SCHEMBL1200585 | 0.79 | HDAC8 (0.71) | HDAC8HDAC6SLC7A5PKMCYP2C9 | |
| SCHEMBL1255459 | 0.79 | MEN1 (0.53) | POLBCYP2C9KMT2AMEN1ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763646-B2 | Compounds for the treatment of alzheimer's disease | ELAN PHARMACEUTICALS, INC. (US) | 2010-07-27 | — | — | US | disclosed |