SCHEMBL30148754

SCHEMBL30148754

Brc1ccc2ccc3c(Br)cccc3c2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.41
HPRT1 P00492 3/20 0.41
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
RXFP1 Q9HBX9 1/20 0.39
ALDH1A1 P00352 4/20 0.38
HIF1A Q16665 1/20 0.38
CYP1B1 Q16678 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CYP2C19 P33261 3/20 0.38
CYP2D6 P10635 2/20 0.38
BACE1 P56817 1/20 0.37
PARP1 P09874 1/20 0.37
CYP1A2 P05177 3/20 0.36
CYP2C9 P11712 2/20 0.36
HPGD P15428 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
AR P10275 1/20 0.36
PNMT P11086 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14973721 1.00 CYP2A6 (0.41) CYP2A6HPRT1MEN1KMT2ARXFP1
SCHEMBL30366448 0.85 CYP2A6 (0.52) CYP2A6MEN1KMT2ARXFP1ALDH1A1
SCHEMBL6562541 0.85 CYP2A6 (0.52) CYP2A6MEN1KMT2ARXFP1ALDH1A1
SCHEMBL2286583 0.83 CYP2C19 (0.51) CYP2A6HPRT1MEN1KMT2ARXFP1
SCHEMBL723041 0.83 HPRT1 (0.64) CYP2A6HPRT1MEN1KMT2ARXFP1
SCHEMBL1234095 0.81 ALDH1A1 (0.50) HPRT1ALDH1A1HIF1ACYP1B1HSD17B10
SCHEMBL1527416 0.80 HPRT1 (0.67) CYP2A6HPRT1MEN1KMT2AALDH1A1
SCHEMBL27107379 0.80 HPRT1 (0.67) CYP2A6HPRT1MEN1KMT2AALDH1A1
SCHEMBL17702481 0.80 CYP2A6 (0.39) CYP2A6HPRT1KMT2AALDH1A1HIF1A
SCHEMBL29595200 0.79 CYP2A6 (0.52) CYP2A6MEN1KMT2AALDH1A1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115521253-B Bibiquinoline derivative compound and application thereof 烟台显华科技集团股份有限公司 2023-04-07 CN disclosed
CN-115521253-A Bibiquinoline derivative compound and application thereof 烟台显华科技集团股份有限公司 2022-12-27 CN disclosed