SCHEMBL30148834

SCHEMBL30148834

O=C1CCCn2c1c(Br)c1cccnc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.38
ALDH1A1 P00352 3/20 0.38
HSD17B10 Q99714 2/20 0.38
USP2 O75604 1/20 0.38
CYP1A2 P05177 1/20 0.38
BCHE P06276 1/20 0.38
CFTR P13569 1/20 0.38
ALOX15 P16050 1/20 0.38
ACHE P22303 1/20 0.38
HKDC1 Q2TB90 1/20 0.38
GOPC Q9HD26 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
PDE4A P27815 1/20 0.38
GSK3B P49841 2/20 0.36
DDB1 Q16531 3/20 0.35
CRBN Q96SW2 3/20 0.35
KMT2A Q03164 2/20 0.34
MEN1 O00255 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28922877 1.00 KDM4E (0.38) KDM4EALDH1A1HSD17B10USP2CYP1A2
SCHEMBL22554261 0.79 DDB1 (0.35) KDM4EALDH1A1HSD17B10USP2CYP1A2
SCHEMBL30148836 0.77 PTGDR2 (0.46)
SCHEMBL16201684 0.76 CDK5 (0.45) KDM4EALDH1A1HSD17B10USP2CYP1A2
SCHEMBL28922903 0.75 KDM4E (0.35) KDM4EALDH1A1HSD17B10USP2CYP1A2
SCHEMBL28922829 0.71 PDE4A (0.36) KDM4EALDH1A1HSD17B10CYP1A2PDE4A
SCHEMBL28922791 0.68 CYP1A2 (0.36) KDM4EALDH1A1HSD17B10USP2CYP1A2
SCHEMBL30148885 0.68 CYP1A2 (0.36) KDM4EALDH1A1HSD17B10USP2CYP1A2
SCHEMBL21227272 0.67 L3MBTL1 (0.39) KDM4EALDH1A1HSD17B10USP2CYP1A2
SCHEMBL6024550 0.67 HTR2A (0.42) KDM4EALDH1A1HSD17B10USP2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115521325-A Boronic acid derivatives 首药控股(北京)股份有限公司 2022-12-27 CN disclosed