Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 11/20 | 0.46 |
| ▸ | ELOC | Q15369 | 3/20 | 0.46 |
| ▸ | ELOB | Q15370 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 6/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24757097 | 0.88 | VHL (0.49) | VHLELOCELOBHDAC3HDAC1 | |
| SCHEMBL27359486 | 0.85 | VHL (0.50) | VHLELOCELOBHDAC3HDAC1 | |
| SCHEMBL30169107 | 0.83 | VHL (0.64) | VHLELOCELOBHDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL30169195 | 0.83 | VHL (0.63) | VHLELOCELOBHDAC3HDAC1 | |
| SCHEMBL24756803 | 0.81 | VHL (0.46) | VHLELOCELOBHDAC3HDAC1 | |
| SCHEMBL31206936 | 0.80 | VHL (0.48) | VHLELOCELOB | |
| SCHEMBL24757837 | 0.80 | VHL (0.48) | VHLELOCELOB | |
| SCHEMBL27360238 | 0.79 | VHL (0.46) | VHLELOCELOB | |
| SCHEMBL34471120 | 0.76 | VHL (0.49) | VHLELOCELOBHDAC3HDAC1 | |
| SCHEMBL31573251 | 0.75 | VHL (0.68) | VHLELOCELOBHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266206-A1 | KRAS INHIBITOR CONJUGATES | ERASCA, INC. (US) | 2022-12-22 | — | — | WO | disclosed |