Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30148982 | 0.91 | KRAS (0.36) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30148987 | 0.82 | KRAS (0.36) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30149131 | 0.81 | GPR119 (0.36) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL25437918 | 0.81 | GPR119 (0.36) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30149022 | 0.81 | GPR119 (0.36) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31669685 | 0.81 | GPR119 (0.36) | KRASMAPK3MAPK1 | |
| SCHEMBL30841170 | 0.81 | GPR119 (0.36) | KRASMAPK3MAPK1 | |
| SCHEMBL30149087 | 0.78 | KRAS (0.40) | KRASMAPK3MAPK1 | |
| SCHEMBL30959903 | 0.77 | KRAS (0.40) | KRAS | |
| SCHEMBL31441816 | 0.77 | KRAS (0.40) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266206-A1 | KRAS INHIBITOR CONJUGATES | ERASCA, INC. (US) | 2022-12-22 | — | — | WO | disclosed |