Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 7/20 | 0.60 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30149537 | 0.88 | TRPC5 (0.55) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL30149487 | 0.88 | TRPC5 (0.55) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL30149376 | 0.87 | TRPC5 (0.55) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL30149383 | 0.87 | TRPC5 (0.55) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL30149467 | 0.87 | TRPC5 (0.56) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL30149460 | 0.86 | TRPC5 (0.54) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL30149323 | 0.86 | TRPC5 (0.56) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL30149292 | 0.85 | TRPC5 (0.53) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL30149505 | 0.85 | TRPC5 (0.57) | TRPC5TRPC4KCNH2TRPC1TP53 | |
| SCHEMBL30149367 | 0.85 | TRPC5 (0.57) | TRPC5TRPC4KCNH2TRPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115636831-B | Fused pyrimidinediones, their use and pharmaceutical compositions | 中国药科大学 | 2024-11-08 | — | — | CN | disclosed |
| CN-115636831-A | Fused pyrimidinediones, their use and pharmaceutical compositions | 中国药科大学 | 2023-01-24 | — | — | CN | disclosed |