Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | AR | P10275 | 8/20 | 0.63 |
| ▸ | PARP1 | P09874 | 1/20 | 0.63 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717747 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL4931969 | 0.85 | LMNA (0.73) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL25310222 | 0.83 | LMNA (0.71) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL9328808 | 0.81 | SMN1; SMN2 (1.00) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL25263355 | 0.81 | LMNA (0.68) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL29651055 | 0.81 | LMNA (0.68) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL462088 | 0.81 | LMNA (0.68) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL2610104 | 0.81 | KDM4E (1.00) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL4817305 | 0.80 | PRMT5 (0.68) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL25310948 | 0.80 | LMNA (0.66) | LMNASMN1; SMN2POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113045582-B | PARP-1/PI3K double-target inhibitor or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 中国药科大学 | 2022-12-23 | — | — | CN | disclosed |