Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.79 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.79 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.79 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ESR1 | P03372 | 2/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.59 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.58 |
| ▸ | DHODH | Q02127 | 4/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PTGES | O14684 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897678 | 0.91 | POLB (0.73) | AKR1C3AKR1C2AKR1C1POLBALDH1A1 | |
| SCHEMBL4614391 | 0.88 | AKR1C3 (1.00) | AKR1C3AKR1C2AKR1C1POLBALDH1A1 | |
| SCHEMBL4601385 | 0.86 | KDM4E (0.67) | AKR1C3AKR1C2AKR1C1POLBALDH1A1 | |
| Benzaldehyde SCHEMBL22471878 | 0.82 | POLB (0.61) | AKR1C3AKR1C2AKR1C1POLBALDH1A1 | |
| SCHEMBL6335134 | 0.81 | POLB (0.76) | AKR1C3AKR1C2AKR1C1POLBALDH1A1 | |
| Iodide SCHEMBL4466354 | 0.79 | POLB (0.74) | AKR1C3AKR1C2AKR1C1POLBALDH1A1 | |
| SCHEMBL31490582 | 0.78 | DHODH (0.80) | AKR1C3AKR1C2AKR1C1ALDH1A1HSD17B10 | |
| SCHEMBL12237496 | 0.76 | RXFP1 (0.67) | AKR1C3AKR1C2AKR1C1POLBALDH1A1 | |
| SCHEMBL3237037 | 0.76 | POLB (1.00) | AKR1C3AKR1C2AKR1C1POLBALDH1A1 | |
| SCHEMBL3232504 | 0.75 | DHODH (0.80) | POLBALDH1A1HSD17B10KDM4EESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546392-B2 | 17Beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of hormone-related diseases | UNIVERSITAET DES SAARLANDES (DE) | 2013-10-01 | — | — | US | disclosed |
| US-20100204234-A1 | 17Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Hormone-Related Diseases | UNIVERSITAET DES SAARLANDES (DE) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204234-A1 | 17Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Hormone-Related Diseases | HSD17B1, HSD17B11, HSD17B2 | AKR1C3 108/4885AKR1C2 80/4885AKR1C1 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.