Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 6/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.39 |
| ▸ | ITGAV | P06756 | 5/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL774573 | 1.00 | ERBB2 (0.51) | ERBB2EGFRLCKKITBRAF | |
| SCHEMBL773111 | 0.88 | EGFR (0.50) | ERBB2EGFRKITBRAFFGFR1 | |
| SCHEMBL30151993 | 0.88 | EGFR (0.50) | ERBB2EGFRKITBRAFFGFR1 | |
| SCHEMBL774604 | 0.86 | LCK (0.50) | EGFRLCKKITBRAFNAMPT | |
| SCHEMBL773549 | 0.83 | LCK (0.52) | LCKNAMPTALDH1A1L3MBTL1 | |
| SCHEMBL774920 | 0.82 | LCK (0.47) | LCKNAMPTALDH1A1KDM4ELMNA | |
| SCHEMBL774149 | 0.80 | LCK (0.55) | LCKNAMPTFGFR1SRCALDH1A1 | |
| SCHEMBL774538 | 0.80 | ALDH1A1 (0.51) | LCKNAMPTALDH1A1KDM4ELMNA | |
| SCHEMBL774389 | 0.79 | LCK (0.55) | EGFRLCKNAMPTALDH1A1L3MBTL1 | |
| SCHEMBL773381 | 0.78 | LCK (0.49) | LCKKITBRAFNAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139305-A1 | HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF | iOmx Therapeutics AG (DE) | 2023-03-01 | — | — | EP | disclosed |