Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 6/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 4/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.32 |
| ▸ | CBL | P22681 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24821801 | 1.00 | CBLB (0.39) | CBLBHSD11B1P2RX7TRPV1SCN9A | |
| SCHEMBL24820229 | 0.91 | CBLB (0.43) | CBLBHSD11B1P2RX7SCN9ACBL | |
| SCHEMBL30153188 | 0.91 | CBLB (0.43) | CBLBHSD11B1P2RX7SCN9ACBL | |
| SCHEMBL24818671 | 0.88 | CBLB (0.39) | CBLBSCN9ACBL | |
| SCHEMBL30152621 | 0.87 | CBLB (0.34) | CBLBHSD11B1P2RX7SCN9ACBL | |
| SCHEMBL30152906 | 0.87 | CBLB (0.33) | CBLBHSD11B1P2RX7SCN9ACBL | |
| SCHEMBL24819959 | 0.87 | CBLB (0.33) | CBLBHSD11B1P2RX7SCN9ACBL | |
| SCHEMBL24818742 | 0.87 | CBLB (0.34) | CBLBHSD11B1P2RX7SCN9ACBL | |
| SCHEMBL24818670 | 0.84 | NPC1 (0.46) | BACE1BACE2MGAMGAASI | |
| SCHEMBL30152881 | 0.84 | NPC1 (0.46) | BACE1BACE2MGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |