Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 9/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.30 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24818773 | 1.00 | CD274 (0.33) | CD274PDCD1LG2PDCD1KCNH2HCRTR1 | |
| SCHEMBL24819868 | 0.92 | CD274 (0.35) | CD274PDCD1LG2PDCD1KCNH2HCRTR1 | |
| SCHEMBL24819863 | 0.87 | CD274 (0.39) | CD274PDCD1LG2PDCD1KCNH2HCRTR1 | |
| SCHEMBL24820696 | 0.86 | S1PR1 (0.32) | — | |
| SCHEMBL30152951 | 0.86 | S1PR1 (0.32) | — | |
| SCHEMBL30152688 | 0.84 | CBLB (0.35) | CD274PDCD1LG2 | |
| SCHEMBL30153020 | 0.84 | CBLB (0.35) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL24819009 | 0.84 | CBLB (0.35) | CD274PDCD1LG2 | |
| SCHEMBL24820102 | 0.84 | CBLB (0.35) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL24819905 | 0.82 | CBLB (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |