Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 5/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.34 |
| ▸ | MGLL | Q99685 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29745576 | 1.00 | TLR9 (0.36) | TLR9TLR8TLR7CNR1SCN8A | |
| SCHEMBL23230974 | 1.00 | TLR9 (0.36) | TLR9TLR8TLR7CNR1SCN8A | |
| SCHEMBL23230756 | 1.00 | TLR9 (0.36) | TLR9TLR8TLR7CNR1SCN8A | |
| SCHEMBL23230755 | 1.00 | TLR9 (0.36) | TLR9TLR8TLR7CNR1SCN8A | |
| Trifluoroacetic Acid SCHEMBL23216076 | 0.93 | DPP4 (0.35) | TLR9TLR8TLR7CNR1SCN8A | |
| Trifluoroacetic Acid SCHEMBL23216073 | 0.93 | DPP4 (0.35) | TLR9TLR8TLR7CNR1SCN8A | |
| SCHEMBL23230381 | 0.91 | CNR1 (0.36) | CNR1MGLLNPSR1HTTCNR2 | |
| SCHEMBL23230791 | 0.90 | TACR3 (0.37) | CNR1MGLLNPSR1HTTCNR2 | |
| SCHEMBL23215713 | 0.90 | TACR3 (0.37) | CNR1MGLLNPSR1HTTCNR2 | |
| SCHEMBL23215710 | 0.90 | TACR3 (0.37) | CNR1MGLLNPSR1HTTCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230023559-A1 | ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D. E. SHAW RESEARCH, LLC (US) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230023559-A1 | ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | KCNJ2, KCNA3, KCNH3 | TLR9 4801/4885TLR8 4263/4885TLR7 3131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.