Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 4/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | ABL2 | P42684 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.47 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 5/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3473013 | 1.00 | LIMK1 (0.59) | LIMK1EGFRABL1ABL2CA5A | |
| SCHEMBL2389718 | 0.79 | EGFR (0.57) | LIMK1EGFRABL1ABL2CA5A | |
| SCHEMBL13209220 | 0.79 | EGFR (0.57) | LIMK1EGFRABL1ABL2CA5A | |
| SCHEMBL30672219 | 0.79 | EGFR (0.57) | LIMK1EGFRABL1ABL2CA5A | |
| SCHEMBL6884961 | 0.79 | EGFR (0.57) | LIMK1EGFRABL1ABL2CA5A | |
| SCHEMBL23885372 | 0.78 | LIMK1 (0.47) | LIMK1RETKDR | |
| SCHEMBL30052198 | 0.78 | LIMK1 (0.47) | LIMK1RETKDR | |
| SCHEMBL1923985 | 0.78 | EGFR (0.63) | EGFRCA5AMAPTKDRKDM4E | |
| Hydrochloric Acid SCHEMBL7218016 | 0.78 | EGFR (0.55) | LIMK1EGFRABL1ABL2CA5A | |
| SCHEMBL13960264 | 0.77 | CHEK1 (0.58) | MAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118894861-A | Novel tricyclic compounds as IRAK4 inhibitors | 韩国化学研究院 | 2024-11-05 | — | — | CN | disclosed |
| CN-113227095-B | Novel tricyclic compounds as IRAK4 inhibitors | 韩国化学研究院 | 2024-07-05 | — | — | CN | disclosed |
| CN-117157297-A | PRMT5 inhibitors | 上海齐鲁制药研究中心有限公司 | 2023-12-01 | — | — | CN | disclosed |
| WO-2023001133-A1 | PRMT5 INHIBITOR | 上海齐鲁制药研究中心有限公司 | 2023-01-26 | — | — | WO | disclosed |