Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.63 |
| ▸ | TYMS | P04818 | 6/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.51 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16009388 | 0.83 | EGFR (0.60) | EGFRTYMSPDGFRBMAPTKDR | |
| SCHEMBL17047835 | 0.83 | EGFR (0.49) | EGFRTYMSPDGFRBMAPTABCB1 | |
| SCHEMBL30254691 | 0.83 | EGFR (0.49) | EGFRTYMSPDGFRBMAPTABCB1 | |
| Hydrochloric Acid SCHEMBL7218035 | 0.81 | EGFR (0.58) | EGFRTYMSPDGFRBMAPTKDR | |
| SCHEMBL3473013 | 0.78 | LIMK1 (0.59) | EGFRMAPTKDRCA5AKDM4E | |
| SCHEMBL30159366 | 0.78 | LIMK1 (0.59) | EGFRMAPTKDRCA5AKDM4E | |
| SCHEMBL12391891 | 0.76 | EGFR (0.63) | EGFRTYMSPDGFRBKDRFLT3 | |
| SCHEMBL17500020 | 0.76 | EGFR (0.59) | EGFRTYMSPDGFRBKDRFLT3 | |
| SCHEMBL12620147 | 0.75 | TYMS (0.61) | EGFRTYMSPDGFRBKDRFLT3 | |
| SCHEMBL1369490 | 0.72 | TYMS (0.61) | EGFRTYMSMAPTCA5AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422297-B2 | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150141445-A1 | Tricyclic Compounds Having Cytostatic and/or Cytotoxic Activity and Methods of Use Thereof | DUQUESNE UNIVERSITY OF THE HOLY GHOST | 2015-05-21 | — | — | US | disclosed |
| EP-1874777-B1 | 1H-PYRIMIDO[4,5-B]INDOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2011-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141445-A1 | Tricyclic Compounds Having Cytostatic and/or Cytotoxic Activity and Methods of Use Thereof | DHFR, TK1, TYMS | EGFR 334/4885TYMS 3/4885PDGFRB 586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.