Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23535659 | 1.00 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL2864348 | 0.84 | NR4A2 (0.40) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL23535768 | 0.83 | TTR (0.43) | SMN1; SMN2KDM4EMAP2K4TTR | |
| SCHEMBL1394029 | 0.79 | MAPT (0.49) | MAPTKDM4ESTAT3HIF1ANR4A2 | |
| SCHEMBL27536113 | 0.76 | MAP2K4 (0.47) | MAP2K4LRRK2KDR | |
| SCHEMBL4150250 | 0.75 | CHEK1 (0.43) | NPC1RAB9ASMN1; SMN2MAPTMAP2K4 | |
| SCHEMBL4150252 | 0.75 | CHEK1 (0.43) | NPC1RAB9ASMN1; SMN2MAPTMAP2K4 | |
| SCHEMBL16759813 | 0.75 | KDM4E (0.41) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL2867525 | 0.74 | ALPL (0.50) | SMN1; SMN2MAP2K4NR4A2CA12KDR | |
| SCHEMBL522062 | 0.73 | CA12 (0.52) | NPC1RAB9ASMN1; SMN2CASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076440-A1 | INHIBITORS OF ENL/AF9 YEATS | The Rockefeller University (US) | 2022-10-26 | — | — | EP | disclosed |