Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.71 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740213 | 1.00 | CRBN (0.71) | CRBNDDB1MEN1KMT2AIKZF3 | |
| SCHEMBL30301972 | 1.00 | CRBN (0.71) | CRBNDDB1MEN1KMT2AIKZF3 | |
| SCHEMBL20812121 | 0.88 | CRBN (0.70) | CRBNDDB1 | |
| SCHEMBL2173374 | 0.88 | CRBN (0.65) | CRBNDDB1IKZF3 | |
| SCHEMBL24319680 | 0.87 | CRBN (0.78) | CRBNDDB1IKZF3 | |
| SCHEMBL15290924 | 0.87 | CRBN (0.63) | CRBNDDB1 | |
| SCHEMBL27395883 | 0.86 | CRBN (0.61) | CRBNDDB1 | |
| SCHEMBL28864225 | 0.85 | CRBN (0.68) | CRBNDDB1IKZF3 | |
| SCHEMBL27267043 | 0.85 | CRBN (0.69) | CRBNDDB1IKZF3 | |
| SCHEMBL19586301 | 0.83 | CRBN (1.00) | CRBNDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4077309-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |