Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.62 |
| ▸ | LCK | P06239 | 18/20 | 0.62 |
| ▸ | EGFR | P00533 | 10/20 | 0.62 |
| ▸ | BTK | Q06187 | 7/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21855161 | 0.91 | JAK3 (0.74) | JAK3LCKEGFRBTK | |
| SCHEMBL23459884 | 0.91 | JAK3 (0.74) | JAK3LCKEGFRBTK | |
| SCHEMBL24833057 | 0.90 | JAK3 (0.67) | JAK3LCKEGFRBTK | |
| SCHEMBL24833611 | 0.89 | LCK (0.63) | JAK3LCKEGFRBTK | |
| SCHEMBL24832891 | 0.88 | JAK3 (0.65) | JAK3LCKEGFRBTK | |
| SCHEMBL21946914 | 0.86 | JAK3 (0.71) | JAK3LCKEGFRBTK | |
| SCHEMBL21855246 | 0.85 | JAK3 (0.74) | JAK3LCKEGFRBTK | |
| SCHEMBL30160906 | 0.84 | BTK (0.59) | JAK3LCKEGFRBTK | |
| SCHEMBL24833034 | 0.83 | LCK (0.78) | JAK3LCKEGFRBTK | |
| SCHEMBL24832893 | 0.83 | JAK3 (0.62) | JAK3LCKEGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115557933-B | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2024-08-16 | — | — | CN | disclosed |
| WO-2023274390-A1 | BRUTON'S TYROSINE KINASE AND MUTANT DEGRADER, COMPOSITION AND APPLICATION THEREOF | 杭州和正医药有限公司 | 2023-01-05 | — | — | WO | disclosed |
| CN-115557933-A | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2023-01-03 | — | — | CN | disclosed |