Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.58 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 4/20 | 0.42 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25450244 | 1.00 | PTGES2 (0.58) | PTGES2SLC22A12CCR2SGK1ACLY | |
| SCHEMBL25450381 | 0.87 | PTGES2 (0.59) | PTGES2CCR2ACLYSLC40A1BRAF | |
| SCHEMBL30216061 | 0.79 | PKLR (0.47) | SLC40A1POLBKMT2AKDM4E | |
| SCHEMBL25450327 | 0.79 | PKLR (0.47) | SLC40A1POLBKMT2AKDM4E | |
| SCHEMBL30161625 | 0.79 | PTGES2 (0.50) | PTGES2CCR2SGK1ACLYPOLB | |
| SCHEMBL25449978 | 0.79 | PTGES2 (0.50) | PTGES2CCR2SGK1ACLYPOLB | |
| SCHEMBL30216035 | 0.77 | PRKD3 (0.52) | ACLYSLC40A1KMT2AKDM4E | |
| SCHEMBL25450405 | 0.77 | GUSB (0.49) | CCR2ACLYPIK3CDPIK3CAPIK3CB | |
| SCHEMBL25450184 | 0.77 | BRAF (0.49) | KMT2ABRAF | |
| SCHEMBL30161469 | 0.77 | GUSB (0.49) | CCR2ACLYPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768750-A | GCN2 modulator compounds | 阿莱斯塔治疗公司 | 2023-03-07 | — | — | CN | disclosed |
| EP-4107146-A1 | GCN2 MODULATOR COMPOUNDS | Alesta Therapeutics BV (NL) | 2022-12-28 | — | — | EP | disclosed |