Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20699329 | 1.00 | IDO1 (0.37) | IDO1TDO2USP30KRASPDE4B | |
| SCHEMBL30161639 | 0.90 | SCN9A (0.36) | USP30KRASPDE4BRXRARXRB | |
| SCHEMBL20699301 | 0.90 | SCN9A (0.36) | USP30KRASPDE4BRXRARXRB | |
| SCHEMBL20699309 | 0.86 | SCN9A (0.41) | IDO1TDO2USP30KRASPDE4B | |
| SCHEMBL30161443 | 0.86 | SCN9A (0.41) | IDO1TDO2USP30KRASPDE4B | |
| SCHEMBL20711762 | 0.84 | PDE4B (0.43) | IDO1TDO2USP30PDE4BCCNK | |
| SCHEMBL29607485 | 0.84 | PDE4B (0.43) | IDO1TDO2USP30PDE4BCCNK | |
| SCHEMBL28385243 | 0.84 | PDE4B (0.43) | IDO1TDO2USP30PDE4BCCNK | |
| SCHEMBL20711872 | 0.83 | RXRA (0.34) | IDO1TDO2RXRARXRBRXRG | |
| SCHEMBL20711770 | 0.82 | KRAS (0.39) | KRASPDE4BRXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032646-B | Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2023-01-03 | — | — | CN | disclosed |