Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Febuxostat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH known ✓ | P47989 | 11/20 | 1.00 |
| ▸ | TARBP2 | Q15633 | 2/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 1.00 |
| ▸ | BLVRB | P30043 | 1/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 1.00 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 1.00 |
| ▸ | PPID | Q08752 | 1/20 | 0.67 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.58 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Febuxostat SCHEMBL29398803 | 1.00 | XDH (1.00) | XDHTARBP2ABCC4ABCB11PGR | |
| Febuxostat SCHEMBL249339 | 1.00 | XDH (1.00) | XDHTARBP2ABCC4ABCB11PGR | |
| Febuxostat SCHEMBL28271887 | 1.00 | XDH (1.00) | XDHTARBP2ABCC4ABCB11PGR | |
| Febuxostat SCHEMBL27935497 | 0.99 | XDH (0.98) | XDHTARBP2ABCC4ABCB11PGR | |
| Febuxostat SCHEMBL27935500 | 0.99 | XDH (0.98) | XDHTARBP2ABCC4ABCB11PGR | |
| Febuxostat SCHEMBL2635494 | 0.98 | XDH (0.96) | XDHTARBP2ABCC4ABCB11PGR | |
| SCHEMBL437353 | 0.92 | XDH (0.85) | XDHTARBP2ABCC4ABCB11PGR | |
| SCHEMBL23417559 | 0.92 | XDH (0.85) | XDHTARBP2ABCC4ABCB11PGR | |
| SCHEMBL16363788 | 0.92 | XDH (0.85) | XDHTARBP2ABCC4ABCB11PGR | |
| SCHEMBL29183567 | 0.91 | XDH (0.83) | XDHTARBP2ABCC4ABCB11PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230001128-A1 | AEROSOLIZATION SYSTEMS, METHODS, AND APPARATUSES | SHUSTER GARY STEPHEN (CA) | 2023-01-05 | — | — | US | disclosed |