Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP4 | P49662 | 1/20 | 0.39 |
| ▸ | CASP5 | P51878 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24852015 | 1.00 | CASP1 (0.39) | CASP1CASP4CASP5RETDRD2 | |
| SCHEMBL24852386 | 0.93 | CHRM2 (0.38) | RETDRD2DRD3MAPK1EGFR | |
| SCHEMBL30162175 | 0.93 | CHRM2 (0.38) | RETDRD2DRD3MAPK1EGFR | |
| SCHEMBL30162461 | 0.83 | RET (0.36) | RETDRD2DRD3MAPK1 | |
| SCHEMBL24852382 | 0.83 | RET (0.36) | RETDRD2DRD3MAPK1 | |
| SCHEMBL24851492 | 0.83 | RET (0.35) | CASP1CASP4CASP5RETDRD2 | |
| SCHEMBL30162176 | 0.83 | RET (0.35) | CASP1CASP4CASP5RETDRD2 | |
| SCHEMBL24852372 | 0.82 | MAPK1 (0.39) | RETDRD2DRD3MAPK1 | |
| SCHEMBL24851484 | 0.81 | RET (0.37) | RETDRD2DRD3MAPK1 | |
| SCHEMBL24851357 | 0.81 | RET (0.37) | RETDRD2DRD3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278483-A1 | COMPOUNDS HAVING 1H-PYRAZOLO[4,3-C]PYRIDIN-6-AMINOS AS THERAPEUTIC AGENTS | LOMOND THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |