Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | BUB1 | O43683 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29218282 | 1.00 | USP30 (0.42) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL16635502 | 0.89 | PIK3CA (0.43) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL868675 | 0.86 | USP30 (0.43) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL31167558 | 0.86 | USP30 (0.43) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL29513830 | 0.84 | CHRM4 (0.45) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL594429 | 0.84 | CHRM4 (0.45) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL22040017 | 0.83 | PIK3CA (0.43) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL25151277 | 0.83 | USP30 (0.49) | USP30PRMT5WDR77BACE1GPR119 | |
| SCHEMBL30935036 | 0.81 | GPR119 (0.33) | USP30PRMT5WDR77BACE1BACE2 | |
| SCHEMBL16375063 | 0.81 | ROCK1 (0.38) | USP30PRMT5WDR77BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377306-A1 | ROCK2 INHIBITORS AND USES THEREOF | President and Fellows of Harvard College (US) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |