Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | GRM5 | P41594 | 5/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20206287 | 1.00 | BTK (0.47) | BTKGRM5ACKR3CDK9KMT2A | |
| SCHEMBL20206285 | 1.00 | BTK (0.47) | BTKGRM5ACKR3CDK9KMT2A | |
| SCHEMBL30165293 | 0.91 | NPC1 (0.46) | BTKGRM5CDK9KMT2AMEN1 | |
| SCHEMBL20206222 | 0.90 | ACKR3 (0.47) | BTKGRM5ACKR3KMT2AL3MBTL1 | |
| SCHEMBL24021477 | 0.89 | GRM5 (0.46) | BTKGRM5ACKR3KMT2AL3MBTL1 | |
| SCHEMBL20206254 | 0.89 | GRM5 (0.46) | BTKGRM5ACKR3KMT2AL3MBTL1 | |
| SCHEMBL21328549 | 0.85 | GRM5 (0.51) | GRM5ACKR3KDM4EBCL6 | |
| SCHEMBL23860688 | 0.85 | GRM5 (0.51) | GRM5ACKR3KDM4EBCL6 | |
| SCHEMBL20206136 | 0.83 | NAMPT (0.45) | GRM5ACKR3KMT2AKDM4EMEN1 | |
| SCHEMBL23860726 | 0.82 | GRM5 (0.48) | GRM5ACKR3BCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043405-A1 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | DANA-FARBER CANCER INSTITUTE, INC. | 2024-02-08 | — | — | US | disclosed |
| EP-4125895-A1 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | Dana-Farber Cancer Institute, Inc. (US) | 2023-02-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240043405-A1 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | IRAK1, IRAK2, IRAK3 | BTK 75/4885GRM5 2994/4885ACKR3 2221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.