Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | HASPIN | Q8TF76 | 3/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1772824 | 1.00 | KMT2A (0.69) | KMT2AAXLGPR84CHEK1LRRK2 | |
| SCHEMBL29768778 | 0.81 | KMT2A (1.00) | KMT2AAXLGPR84CHEK1LRRK2 | |
| SCHEMBL28322044 | 0.81 | KMT2A (0.69) | KMT2AAXLGPR84CHEK1LRRK2 | |
| SCHEMBL257134 | 0.81 | KMT2A (1.00) | KMT2AAXLGPR84CHEK1LRRK2 | |
| SCHEMBL17875019 | 0.81 | KMT2A (0.69) | KMT2AAXLGPR84CHEK1LRRK2 | |
| SCHEMBL29768777 | 0.81 | KMT2A (1.00) | KMT2AAXLGPR84CHEK1LRRK2 | |
| SCHEMBL28007617 | 0.81 | KMT2A (0.69) | KMT2AAXLGPR84CHEK1LRRK2 | |
| SCHEMBL3563747 | 0.77 | KMT2A (0.63) | KMT2AAXLGPR84CHEK1LRRK2 | |
| SCHEMBL28784312 | 0.77 | KMT2A (0.63) | KMT2AAXLGPR84CHEK1LRRK2 | |
| SCHEMBL3563749 | 0.77 | KMT2A (0.63) | KMT2AAXLGPR84CHEK1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110402248-B | Azaindoles as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-06 | — | — | CN | disclosed |