Sugi Predict

Sugi Predict / Compounds / SCHEMBL257134

SCHEMBL257134

SCHEMBL257134

O=Cc1c[nH]c2ncccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 1.00
▸ AXL P30530 1/20 0.55
▸ GPR84 Q9NQS5 1/20 0.53
▸ CHEK1 O14757 2/20 0.52
▸ CYP2A6 P11509 1/20 0.52
▸ IMPDH2 P12268 1/20 0.52
▸ HASPIN Q8TF76 4/20 0.50
▸ MET P08581 2/20 0.50
▸ CCNT1 O60563 2/20 0.50
▸ CDK9 P50750 2/20 0.50
▸ LRRK2 Q5S007 1/20 0.50
▸ MAP2K1 Q02750 1/20 0.49
▸ TRIM24 O15164 1/20 0.46
▸ TRIM33 Q9UPN9 1/20 0.46
▸ CAMKK2 Q96RR4 1/20 0.45
▸ PDPK1 O15530 1/20 0.45
▸ TGFBR1 P36897 1/20 0.45
▸ IKBKE Q14164 1/20 0.45
▸ KDM4E B2RXH2 1/20 0.45
▸ MEN1 O00255 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29768777 1.00 KMT2A (1.00) KMT2AAXLGPR84CHEK1CYP2A6
SCHEMBL29768778 1.00 KMT2A (1.00) KMT2AAXLGPR84CHEK1CYP2A6
Alcohol SCHEMBL27754790 0.91 KMT2A (0.82) KMT2AAXLGPR84CHEK1CYP2A6
SCHEMBL15331287 0.83 KMT2A (0.71) KMT2AAXLGPR84CHEK1HASPIN
SCHEMBL15331290 0.83 KMT2A (0.71) KMT2AAXLGPR84CHEK1HASPIN
SCHEMBL4597800 0.82 KMT2A (0.68) KMT2AAXLGPR84CHEK1CYP2A6
SCHEMBL1772824 0.81 KMT2A (0.69) KMT2AAXLGPR84CHEK1HASPIN
SCHEMBL17875019 0.81 KMT2A (0.69) KMT2AAXLGPR84CHEK1HASPIN
SCHEMBL30165674 0.81 KMT2A (0.69) KMT2AAXLGPR84CHEK1HASPIN
SCHEMBL28007617 0.81 KMT2A (0.69) KMT2AAXLGPR84CHEK1HASPIN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 684 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240294522-A1 3-SUBSTITUTED 1H-PYRROLO[2,3-B]PYRIDINE AS GRK5 MODULATORS LEAD DISCOVERY CENTER GMBH (DE) 2024-09-05 — — US claimed
CN-117916239-A 3-Substituted 1H-pyrrolo [2,3-b ] pyridines as GRK5 modulators 利德探索中心股份有限公司 2024-04-19 — — CN claimed
EP-4313294-A1 3-SUBSTITUTED 1H-PYRROLO[2,3-B]PYRIDINE AS GRK5 MODULATORS Lead Discovery Center GmbH (DE) 2024-02-07 — — EP claimed
CN-114106018-B Metal ion detection fluorescent probe based on purine parent, and preparation method and application thereof 江苏科技大学 2023-07-25 — — CN claimed
WO-2022263548-A1 3-SUBSTITUTED 1H-PYRROLO[2,3-B]PYRIDINE AS GRK5 MODULATORS LEAD DISCOVERY CENTER GMBH (DE) 2022-12-22 — — WO claimed
EP-4104901-A1 3-SUBSTITUTED 1H-PYRROLO[2,3-B]PYRIDINE AS GRK5 MODULATORS Lead Discovery Center GmbH (DE) 2022-12-21 — — EP claimed
CN-113861194-B Pyrrolopyridine-containing bisamide imidazole compound and preparation method and application thereof 英维沃化工科技(广州)有限公司 2022-07-05 — — CN claimed
CN-114106018-A Purine matrix-based metal ion detection fluorescent probe and preparation method and application thereof 江苏科技大学 2022-03-01 — — CN claimed
CN-113861194-A Pyrrolopyridine-containing bisamide imidazole compound and preparation method and application thereof 英维沃化工科技(广州)有限公司 2021-12-31 — — CN claimed
CN-112409353-A Preparation method of 7-azaindole derivative 苏州艾缇克药物化学有限公司 2021-02-26 — — CN claimed
CN-110291089-A Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death 海帕瑞吉尼克斯股份有限公司 2019-09-27 — — CN claimed
CN-109456321-A A kind of synthetic method of 7- azaindole -3- formaldehyde 嘉兴市秀洲区洪合镇中学 2019-03-12 — — CN claimed
CN-106279154-A A kind of preparation method of 7 azaindole 3 formaldehyde 叶芳 2017-01-04 — — CN claimed
EP-2724156-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASE The Jackson Laboratory (US) 2014-04-30 — — EP claimed
CN-103765212-A Methods and compositions for treating cancer and autoimmune diseases JACKSON LAB 2014-04-30 — — CN claimed
WO-2013003112-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASE THE JACKSON LABORATORY (US) 2013-01-03 — — WO claimed
US-20260092034-A1 7-AZAINDOLE ANALOGS AND METHODS OF TREATING NEUROLOGICAL DISORDERS USING THE SAME KULEON LLC (US) 2026-04-02 — — US disclosed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 — — US disclosed
US-4390693-A BACTERICIDE MERCK & CO., INC. (US) 1983-06-28 — — US disclosed
US-4255423-A BACTERICIDES MERCK & CO., INC. (US) 1981-03-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092034-A1 7-AZAINDOLE ANALOGS AND METHODS OF TREATING NEUROLOGICAL DISORDERS USING THE SAME HTR2C, HTR7, HTR6 KMT2A 1166/4885AXL 3119/4885GPR84 277/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH KMT2A 3729/4885AXL 3890/4885GPR84 266/4885
US-20240294522-A1 3-SUBSTITUTED 1H-PYRROLO[2,3-B]PYRIDINE AS GRK5 MODULATORS GRK5, GRK3, GRK4 KMT2A 2260/4885AXL 2226/4885GPR84 255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.