Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | CAMK1D | Q8IU85 | 15/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.33 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.33 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.33 |
| ▸ | PNCK | Q6P2M8 | 1/20 | 0.33 |
| ▸ | CAMK1G | Q96NX5 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30160759 | 0.81 | JAK3 (0.52) | BTKLCKJAK3 | |
| SCHEMBL30160681 | 0.81 | JAK3 (0.52) | BTKLCKJAK3 | |
| SCHEMBL30165835 | 0.80 | LCK (0.35) | BTKCAMK1DLCKJAK3 | |
| SCHEMBL30415191 | 0.80 | HDAC6 (0.44) | CAMK1DPIP5K1CCYP2C9CYP2C19RIPK4 | |
| SCHEMBL30165816 | 0.80 | JAK3 (0.42) | BTKLCKJAK3 | |
| SCHEMBL30165878 | 0.79 | BTK (0.41) | BTKCAMK1DLCKJAK3 | |
| SCHEMBL31052385 | 0.79 | LCK (0.35) | BTKCAMK1DPIP5K1CCYP2C9CYP2C19 | |
| SCHEMBL31052405 | 0.79 | LCK (0.35) | BTKCAMK1DPIP5K1CCYP2C9CYP2C19 | |
| SCHEMBL30160951 | 0.78 | JAK3 (0.40) | BTKCAMK1DPIP5K1CCYP2C9CYP2C19 | |
| SCHEMBL30165804 | 0.78 | JAK3 (0.49) | BTKLCKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115557933-B | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-115557933-A | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2023-01-03 | — | — | CN | disclosed |