Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | BCL6 | P41182 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24105197 | 1.00 | EGFR (0.35) | EGFRAURKAIGF1RPTK6ALDH1A1 | |
| SCHEMBL24105046 | 0.93 | AURKA (0.35) | EGFRAURKAIGF1RALDH1A1L3MBTL1 | |
| SCHEMBL30167778 | 0.93 | AURKA (0.35) | EGFRAURKAIGF1RALDH1A1L3MBTL1 | |
| SCHEMBL24105196 | 0.92 | EGFR (0.34) | EGFRPTK6ALDH1A1L3MBTL1CYP19A1 | |
| Hydrochloric Acid SCHEMBL25174188 | 0.91 | EGFR (0.34) | EGFRPTK6ALDH1A1L3MBTL1CYP19A1 | |
| SCHEMBL25447130 | 0.88 | BRD4 (0.38) | EGFRIGF1RPTK6BCL6AURKB | |
| SCHEMBL22156708 | 0.87 | EGFR (0.38) | EGFRAURKAIGF1RPTK6CSF1R | |
| SCHEMBL22123511 | 0.85 | PTK6 (0.41) | EGFRIGF1RPTK6CSF1RCDK1 | |
| SCHEMBL24105194 | 0.84 | AURKA (0.33) | AURKAALDH1A1L3MBTL1CYP19A1CDK4 | |
| Hydrochloric Acid SCHEMBL30168158 | 0.84 | AURKA (0.32) | AURKAALDH1A1L3MBTL1CYP19A1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667264-A | Novel imidazo-pyrazine derivatives | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | claimed |
| CN-115667264-A | Novel imidazo-pyrazine derivatives | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |