Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3998711 | 0.97 | ALOX5 (0.51) | ALOX5PTGS2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL3998710 | 0.97 | ALOX5 (0.51) | ALOX5PTGS2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL29535850 | 0.97 | ALOX5 (0.51) | ALOX5PTGS2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL29785796 | 0.97 | ALOX5 (0.51) | ALOX5PTGS2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL3012002 | 0.95 | ALOX5 (0.50) | ALOX5PTGS2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6533683 | 0.95 | ALOX5 (0.50) | ALOX5PTGS2SMN1; SMN2KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL6531105 | 0.94 | ALOX5 (0.49) | ALOX5PTGS2SMN1; SMN2KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL30839924 | 0.94 | ALOX5 (0.50) | ALOX5PTGS2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL3016845 | 0.91 | ALOX5 (0.47) | ALOX5PTGS2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL13321375 | 0.91 | ALOX5 (0.49) | ALOX5PTGS2SMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278239-B2 | Polycarbonates made using highly selective catalysts | CORNELL RESEARCH FOUNDATION, INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-20100204437-A1 | POLYCARBONATES MADE USING HIGHLY SELECTIVE CATALYSTS | CORNELL RESEARCH FOUNDATION, INC. (US) | 2010-08-12 | — | — | US | disclosed |
| US-7723256-B2 | Polycarbonates made using highly selective catalysts | CORNELL RESEARCH FOUNDATION, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-7674873-B2 | Polycarbonates made using highly selective catalysts | CORNELL RESEARCH FOUNDATION, INC. (US) | 2010-03-09 | — | — | US | disclosed |
| US-20080108499-A1 | Polycarbonates made using highly selective catalysts | CORNELL RESEARCH FOUNDATION INC. (US) | 2008-05-08 | — | — | US | disclosed |
| US-7304172-B2 | Polycarbonates made using highly selective catalysts | CORNELL RESEARCH FOUNDATION, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-20070255039-A1 | Polycarbonates made using highly selective catalysts | CORNELL RESEARCH FOUNDATION, INC. (US) | 2007-11-01 | — | — | US | disclosed |
| US-20060089252-A1 | Polycarbonates made using highly selective catalysts | CORNELL RESEARCH FOUNDATION, INC. (US) | 2006-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204437-A1 | POLYCARBONATES MADE USING HIGHLY SELECTIVE CATALYSTS | POF1B, PUF60, PARN | ALOX5 2221/4885PTGS2 1897/4885SMN1; SMN2 3898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.