SCHEMBL30168445

SCHEMBL30168445

Cc1ccc(Br)c(OC(F)F)n1

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MBOAT4 Q96T53 3/20 0.43
LPAR1 Q92633 12/20 0.34
CYP3A4 P08684 5/20 0.34
CCR1 P32246 2/20 0.32
RAB9A P51151 1/20 0.32
CCR5 P51681 1/20 0.32
CCR8 P51685 1/20 0.31
TRPV4 Q9HBA0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19851268 1.00 MBOAT4 (0.43) MBOAT4LPAR1CYP3A4CCR1RAB9A
SCHEMBL1840667 0.82 MEN1 (0.36) MBOAT4CCR1RAB9ACCR5CCR8
SCHEMBL21585390 0.80 LPAR1 (0.36) LPAR1CYP3A4CCR1RAB9ACCR5
SCHEMBL19837306 0.78 MBOAT4 (0.39) MBOAT4TRPV4
SCHEMBL29210904 0.77 MBOAT4 (0.38) MBOAT4TRPV4
SCHEMBL30271311 0.77 MBOAT4 (0.38) MBOAT4TRPV4
SCHEMBL19837520 0.77 MBOAT4 (0.43) MBOAT4TRPV4
SCHEMBL19844889 0.77 MBOAT4 (0.38) MBOAT4TRPV4
SCHEMBL21582555 0.77 LPAR1 (0.34) MBOAT4LPAR1CYP3A4CCR1RAB9A
SCHEMBL29813506 0.77 LPAR1 (0.34) MBOAT4LPAR1CYP3A4CCR1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4415706-A1 SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF Vanqua Bio, Inc. (US) 2024-08-21 EP disclosed
WO-2023064343-A1 SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF VANQUA BIO, INC. (US) 2023-04-20 WO disclosed
WO-2023014907-A1 LPAR1 ANTAGONISTS AND USES THEREOF Pipeline Therapeutics, Inc. (US) 2023-02-09 WO disclosed