Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23860768 | 1.00 | KDM4E (0.53) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL901375 | 0.84 | MEN1 (0.60) | KDM4EMEN1KMT2AADORA2AADORA1 | |
| SCHEMBL4000527 | 0.84 | KDM4E (0.52) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL20396108 | 0.82 | CYP1A2 (0.52) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL13868443 | 0.80 | NQO2 (0.52) | HSP90AA1HSP90AB1MEN1ADORA2AALDH1A1 | |
| SCHEMBL3156245 | 0.78 | ADORA2A (0.66) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL6118317 | 0.77 | KDM4E (0.60) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL4257749 | 0.77 | MEN1 (0.79) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL2327791 | 0.75 | LMNA (0.63) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL26626435 | 0.75 | KDM4E (0.58) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116507626-A | Compositions and methods for modulating short-chain dehydrogenase activity | 罗迪奥治疗公司 | 2023-07-28 | — | — | CN | disclosed |
| EP-4126843-A1 | SUBSTITUTED OXOISOINDOLINE COMPOUNDS FOR THE TREATMENT OF CANCER | Bristol-Myers Squibb Company (US) | 2023-02-08 | — | — | EP | disclosed |