SCHEMBL30169832

SCHEMBL30169832

CNC(CCCCB(O)O)(CCN1CCc2ccccc2C1)C(=O)O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ARG1 P05089 5/20 0.69
ARG2 P78540 3/20 0.69
KDM4E B2RXH2 1/20 0.47
ALOX15 P16050 1/20 0.47
HDAC3 O15379 2/20 0.47
HDAC1 Q13547 2/20 0.47
HDAC8 Q9BY41 2/20 0.47
NCOR2 Q9Y618 2/20 0.47
HDAC2 Q92769 1/20 0.47
DRD2 P14416 5/20 0.46
DRD3 P35462 3/20 0.46
HTR1A P08908 1/20 0.46
HTR2A P28223 1/20 0.46
SLC6A4 P31645 1/20 0.46
HTR7 P34969 1/20 0.46
HRH1 P35367 1/20 0.46
HTR2B P41595 1/20 0.46
PRMT5 O14744 3/20 0.45
WDR77 Q9BQA1 3/20 0.45
MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16240844 1.00 ARG1 (0.69) ARG1ARG2KDM4EALOX15HDAC3
SCHEMBL30169882 0.94 ARG1 (0.67) ARG1ARG2KDM4EALOX15
SCHEMBL14879601 0.94 ARG1 (0.67) ARG1ARG2KDM4EALOX15
SCHEMBL14896850 0.87 ARG1 (0.52) ARG1ARG2KDM4EALOX15HDAC3
SCHEMBL14879571 0.86 ARG1 (0.56) ARG1ARG2DRD2DRD3HTR1A
SCHEMBL30169808 0.86 ARG1 (0.56) ARG1ARG2DRD2DRD3HTR1A
SCHEMBL30169876 0.82 ARG1 (1.00) ARG1ARG2KDM4EALOX15HDAC3
SCHEMBL895005 0.82 ARG1 (1.00) ARG1ARG2KDM4EALOX15HDAC3
SCHEMBL14897142 0.81 ARG1 (0.49) ARG1ARG2KDM4EALOX15HDAC3
Hydrochloric Acid SCHEMBL894310 0.81 ARG1 (0.98) ARG1ARG2KDM4EALOX15HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023283332-A1 USES OF ARGINASE INHIBITORS FOR MANAGING KIDNEY DISEASE AND CARDIOVASCULAR CONDITIONS EMORY UNIVERSITY (US) 2023-01-12 WO disclosed