Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clemastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 14/20 | 0.84 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.84 |
| ▸ | HTR1A | P08908 | 2/20 | 0.84 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.84 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.84 |
| ▸ | DRD1 | P21728 | 2/20 | 0.84 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.84 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.84 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.84 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.84 |
| ▸ | DRD3 | P35462 | 2/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clemastine SCHEMBL41468 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL18787212 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL27597691 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL28170352 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL4098555 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL33403 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL15526489 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL4102782 | 0.94 | CYP3A4 (0.89) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL23785540 | 0.92 | CHRM3 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL4087919 | 0.92 | CHRM3 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160272729-A1 | METHOD OF TREATING A PATHOLOGICAL SYNDROME AND A PHARMACEUTICAL AGENT | EPSHTEIN OLEG ILIICH (RU) | 2016-09-22 | — | — | US | disclosed |
| US-20160229914-A1 | METHOD OF TREATING A PATHOLOGICAL SYNDROME | EPSHTEIN OLEG ILIICH (RU) | 2016-08-11 | — | — | US | disclosed |
| US-9382332-B2 | Method of treating a pathological syndrome and a pharmaceutical agent | OLEG ILIICH EPSHTEIN (RU) | 2016-07-05 | — | — | US | disclosed |
| US-20160184256-A1 | METHOD OF TREATING DISORDERS OF THE CARDIOVASCULAR SYSTEM AND A PHARMACEUTICAL AGENT | EPSHTEIN OLEG ILIICH (RU) | 2016-06-30 | — | — | US | disclosed |
| US-20160176987-A1 | METHOD OF TREATING A PATHOLOGICAL SYNDROME AND A PHARMACEUTICAL AGENT | EPSHTEIN OLEG ILIICH (RU) | 2016-06-23 | — | — | US | disclosed |
| US-20160137750-A1 | METHOD OF TREATING A PATHOLOGICAL SYNDROME | EPSHTEIN OLEG IIIICH (RU) | 2016-05-19 | — | — | US | disclosed |
| US-9303091-B2 | Method of treating disorders of the cardiovascular system and a pharmaceutical agent | Epshtein, Oleg Iliich (RU) | 2016-04-05 | — | — | US | disclosed |
| US-9303090-B2 | Method of treating a pathological syndrome and a pharmaceutical agent | Epshtein, Oleg Iliich (RU) | 2016-04-05 | — | — | US | disclosed |
| US-9273117-B2 | Method for administering homeopathically potentized antibody | OLEG ILIICH EPSHTEIN (RU) | 2016-03-01 | — | — | US | disclosed |
| US-9228024-B2 | Method of treating hypertension disorder and a pharmaceutical agent | EPSHTEIN, OLEG I. (RU) | 2016-01-05 | — | — | US | disclosed |
| US-20100221258-A1 | Method of treating a pathological syndrome and a pharmaceutical agent | Epshtein, Oleg Iliich (RU) | 2010-09-02 | — | — | US | disclosed |
| US-20100203059-A1 | METHOD OF TREATING A PATHOLOGICAL SYNDROME AND A PHARMACEUTICAL AGENT | OLEG ILIICH EPSHTEIN (RU) | 2010-08-12 | — | — | US | disclosed |
| US-20100166762-A1 | METHOD OF TREATING A PATHOLOGICAL SYNDROME | Epshtein, Oleg Iliich (RU) | 2010-07-01 | — | — | US | disclosed |
| US-20080131440-A1 | Method of treating a pathological syndrome and a pharmaceutical agent | Epshtein, Oleg I. (RU) | 2008-06-05 | — | — | US | disclosed |
| US-20080050360-A1 | Method of treating a pathological syndrome and a pharmaceutical agent | EPSHTEIN, OLEG I. (RU) | 2008-02-28 | — | — | US | disclosed |
| US-20080050392-A1 | Method of treating a pathological syndrome and a pharmaceutical agent | ILIICH EPSHTEIN O | 2008-02-28 | — | — | US | disclosed |
| US-20080025985-A1 | Method of treating a pathological syndrome and a pharmaceutical agent | EPSHTEIN, OLEG I. (RU) | 2008-01-31 | — | — | US | disclosed |
| US-20080019982-A1 | Method of treating a pathological syndrome and a pharmaceutical agent | EPSHTEIN, OLEG I. (RU) | 2008-01-24 | — | — | US | disclosed |
| US-20070224187-A1 | Method of treating a pathological syndrome and a pharmaceutical agent | EPSHTEIN, OLEG I. (RU) | 2007-09-27 | — | — | US | disclosed |
| US-20030099636-A1 | Curing method for pathologic syndrome and medicinal preparation | EPSHTEIN, OLEG I. (RU) | 2003-05-29 | — | — | US | disclosed |