Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clemastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 14/20 | 0.84 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.84 |
| ▸ | HTR1A | P08908 | 2/20 | 0.84 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.84 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.84 |
| ▸ | DRD1 | P21728 | 2/20 | 0.84 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.84 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.84 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.84 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.84 |
| ▸ | DRD3 | P35462 | 2/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clemastine SCHEMBL41468 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL18787212 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL27597691 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL28170352 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL4098555 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL15526489 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL3017168 | 1.00 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL4102782 | 0.94 | CYP3A4 (0.89) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL23785540 | 0.92 | CHRM3 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA | |
| Clemastine SCHEMBL4087919 | 0.92 | CHRM3 (1.00) | CYP3A4SMN1; SMN2MEN1GMNNLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10631 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121740927-B | Quartz gene identification method based on scanning electron microscope multi-mode signal fusion | Institute of Mineral Resources, Chinese Academy of Geological Sciences (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-121557262-B | V-shaped gear box | 杭州萧山江南通用机械有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122040000-A | Self-adaptive clamping jaw device for clamping anchor rod and drill rod | 安徽理工大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122046794-A | Double-coefficient compensation method for improving simulation precision of strip-method construction concrete temperature field | 湖北工业大学 | 2026-05-15 | — | — | CN | claimed |
| CN-116491926-B | Infant brain T2 weighted magnetic resonance imaging optimization method | 浙江大学 | 2026-05-12 | — | — | CN | claimed |
| CN-122023933-A | Tomato dynamic growth monitoring method based on robot inspection and digital twin | 中国农业大学 | 2026-05-12 | — | — | CN | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| CN-121579957-A | Rotary machine fault diagnosis method for AHO-VMD-CNN-BiGRU | 宜宾职业技术学院 | 2026-02-27 | — | — | CN | claimed |
| CN-121187142-B | Indoor action planning and action control method and system for humanoid robot and robot | 湖南超能机器人技术有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| EP-0608320-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0582380-A1 | Dry granulation using a fluidized bed | McNEIL-PPC, INC. (US) | 1994-02-09 | — | — | EP | claimed |
| WO-1994002176-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER | THE PROCTER & GAMBLE COMPANY (US) | 1994-02-03 | — | — | WO | claimed |
| US-5273758-A | Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms | SANDOZ LTD. (CH) | 1993-12-28 | — | — | US | claimed |
| EP-0284913-B1 | MAGNETIC-RECORDING MEDIUM FOR TESTING, ESPECIALLY FOR GAUGING MAGNETIC FLYING HEADS | BASF Aktiengesellschaft (DE) | 1993-05-26 | — | — | EP | claimed |
| WO-1993007902-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | claimed |
| EP-0316345-A1 | LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE | LIPOSOME TECHNOLOGY, INC. (US) | 1989-05-24 | — | — | EP | claimed |
| EP-0316345-A4 | LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE. | LIPOSOME TECHNOLOGY INC (US) | 1989-05-16 | — | — | EP | claimed |
| WO-1988000824-A1 | LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE | LIPOSOME TECHNOLOGY, INC. (US) | 1988-02-11 | — | — | WO | claimed |