Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 9/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | MERTK | Q12866 | 3/20 | 0.48 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.48 |
| ▸ | SELP | P16109 | 5/20 | 0.47 |
| ▸ | AURKA | O14965 | 5/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 3/20 | 0.47 |
| ▸ | PAK4 | O96013 | 3/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | INSR | P06213 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | AKT1 | P31749 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3017215 | 1.00 | TYRO3 (0.48) | TYRO3FLT3MERTKGAS6SELP | |
| SCHEMBL16087253 | 0.89 | TYRO3 (0.46) | TYRO3FLT3MERTKGAS6SELP | |
| SCHEMBL10271650 | 0.86 | SSTR4 (0.48) | TYRO3FLT3MERTKGAS6SELP | |
| SCHEMBL871647 | 0.85 | TYRO3 (0.47) | TYRO3FLT3MERTKGAS6SELP | |
| SCHEMBL871646 | 0.85 | TYRO3 (0.47) | TYRO3FLT3MERTKGAS6SELP | |
| SCHEMBL870326 | 0.85 | SSTR4 (0.46) | TYRO3FLT3MERTKGAS6SELP | |
| SCHEMBL4110540 | 0.84 | MCHR1 (0.40) | TYRO3FLT3MERTKGAS6MAP4K4 | |
| SCHEMBL4110544 | 0.84 | MCHR1 (0.40) | TYRO3FLT3MERTKGAS6MAP4K4 | |
| SCHEMBL4107426 | 0.80 | HPGD (0.40) | TYRO3MERTKMAPK1MAP4K4MCHR1 | |
| SCHEMBL4107432 | 0.80 | HPGD (0.40) | TYRO3MERTKMAPK1MAP4K4MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | ALCON RESEARCH, LTD. | 2010-08-12 | — | — | US | disclosed |
| US-20090124596-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124596-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | TYRO3 3353/4885FLT3 3213/4885MERTK 3865/4885 |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | PDE4A, PDE4B, PDE5A | TYRO3 3522/4885FLT3 2839/4885MERTK 3382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.