Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 9/20 | 0.46 |
| ▸ | AURKA | O14965 | 7/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | SELP | P16109 | 6/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | MERTK | Q12866 | 2/20 | 0.46 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.46 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.44 |
| ▸ | IKBKB | O14920 | 4/20 | 0.44 |
| ▸ | PAK4 | O96013 | 4/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.44 |
| ▸ | ABL1 | P00519 | 4/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | INSR | P06213 | 4/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3017210 | 0.89 | TYRO3 (0.48) | TYRO3AURKAAURKBSELPFLT3 | |
| SCHEMBL3017215 | 0.89 | TYRO3 (0.48) | TYRO3AURKAAURKBSELPFLT3 | |
| SCHEMBL10271650 | 0.84 | SSTR4 (0.48) | TYRO3AURKAAURKBSELPFLT3 | |
| SCHEMBL871646 | 0.83 | TYRO3 (0.47) | TYRO3AURKAAURKBSELPFLT3 | |
| SCHEMBL871647 | 0.83 | TYRO3 (0.47) | TYRO3AURKAAURKBSELPFLT3 | |
| SCHEMBL870326 | 0.83 | SSTR4 (0.46) | TYRO3AURKAAURKBSELPFLT3 | |
| SCHEMBL4110540 | 0.73 | MCHR1 (0.40) | TYRO3FLT3MERTKGAS6MCHR1 | |
| SCHEMBL4110544 | 0.73 | MCHR1 (0.40) | TYRO3FLT3MERTKGAS6MCHR1 | |
| SCHEMBL8178773 | 0.72 | MCHR1 (0.40) | TYRO3FLT3MERTKGAS6MCHR1 | |
| SCHEMBL870853 | 0.72 | IRAK4 (0.44) | TYRO3FLT3MERTKGAS6MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2106396-B1 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ALCON RES LTD (US) | 2014-09-24 | — | — | EP | disclosed |