Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 4/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14996503 | 0.81 | PARP1 (0.57) | HTR2AHTR2CHTR2BPARP1GRM1 | |
| SCHEMBL20325595 | 0.78 | HTR2A (0.42) | HTR2AHTR2CHTR2BPARP1GRM1 | |
| SCHEMBL803070 | 0.74 | HTR2A (0.43) | HTR2AHTR2CHTR2BPARP1GRM1 | |
| SCHEMBL6096596 | 0.74 | GRM1 (0.40) | HTR2AHTR2CHTR2BPARP1GRM1 | |
| SCHEMBL805487 | 0.74 | PARP1 (0.47) | HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL18086769 | 0.74 | P2RX7 (0.41) | HTR2AHTR2CHTR2BPARP1GRM1 | |
| SCHEMBL2024995 | 0.71 | PARP1 (0.64) | PARP1 | |
| SCHEMBL2023284 | 0.70 | PARP1 (0.52) | PARP1 | |
| SCHEMBL10085808 | 0.68 | TP53 (0.54) | HTR2AHTR2CHTR2BPARP1GRM1 | |
| SCHEMBL4716459 | 0.68 | BDKRB1 (0.47) | HTR2AHTR2CHTR2BPARP1GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380565-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| WO-2023015199-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2023-02-09 | — | — | WO | disclosed |