Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25014486 | 1.00 | PI4KA (0.42) | PI4KAPI4K2BPI4K2API4KBYTHDC1 | |
| SCHEMBL16714533 | 0.83 | PI4KA (0.45) | PI4KAPI4K2BPI4K2API4KBYTHDC1 | |
| SCHEMBL30332427 | 0.83 | PI4KA (0.45) | PI4KAPI4K2BPI4K2API4KBYTHDC1 | |
| SCHEMBL12702562 | 0.81 | PI4KA (0.44) | PI4KAPI4K2BPI4K2API4KBP2RX7 | |
| SCHEMBL13389895 | 0.80 | PI4KA (0.58) | PI4KAPI4K2BPI4K2API4KBCCNE1 | |
| SCHEMBL21126197 | 0.78 | PI4KA (0.41) | PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL21511222 | 0.78 | PI4KA (0.41) | PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL30173097 | 0.77 | CDK1 (0.50) | YTHDC1CCNE2CCNE1CDK2 | |
| SCHEMBL4378141 | 0.77 | CDK1 (0.50) | YTHDC1CCNE2CCNE1CDK2 | |
| SCHEMBL12702671 | 0.76 | PI4KA (0.43) | PI4KAPI4K2BPI4K2API4KBYTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380937-A1 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR PROTEINS | Rayzebio, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-118176194-A | Conjugates comprising covalent binding agents for targeting intracellular proteins | 瑞择生物公司 | 2024-06-11 | — | — | CN | disclosed |
| WO-2023014988-A1 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR PROTEINS | RAYZEBIO, INC. (US) | 2023-02-09 | — | — | WO | disclosed |