Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.59 |
| ▸ | JAK2 | O60674 | 14/20 | 0.59 |
| ▸ | HPGDS | O60760 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 12/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28608390 | 1.00 | JAK1 (0.59) | JAK1JAK2HPGDSJAK3AURKA | |
| SCHEMBL2105053 | 0.82 | JAK1 (0.60) | JAK1JAK2HPGDSJAK3AURKA | |
| SCHEMBL10125409 | 0.82 | JAK1 (0.60) | JAK1JAK2HPGDSJAK3AURKA | |
| SCHEMBL1717444 | 0.82 | JAK1 (0.60) | JAK1JAK2HPGDSJAK3AURKA | |
| SCHEMBL15203406 | 0.82 | JAK1 (0.60) | JAK1JAK2HPGDSJAK3AURKA | |
| SCHEMBL1934804 | 0.82 | JAK2 (0.60) | JAK1JAK2HPGDSJAK3AURKA | |
| SCHEMBL18855883 | 0.80 | JAK1 (0.59) | JAK1JAK2HPGDSJAK3 | |
| SCHEMBL1718163 | 0.80 | JAK1 (0.60) | JAK1JAK2HPGDSJAK3TYK2 | |
| SCHEMBL14697180 | 0.80 | JAK1 (0.58) | JAK1JAK2HPGDSJAK3 | |
| SCHEMBL16477537 | 0.78 | JAK1 (0.60) | JAK1JAK2HPGDSJAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113200983-B | Compound with pyrrolopyridine structure, preparation method and medical application | 中国药科大学 | 2023-01-03 | — | — | CN | disclosed |