Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.50 |
| ▸ | AXL | P30530 | 2/20 | 0.50 |
| ▸ | CDK8 | P49336 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28603796 | 1.00 | PRKCI (0.50) | PRKCIAXLCDK8JAK2JAK3 | |
| SCHEMBL12346324 | 0.79 | CCNK (0.48) | PRKCIAXLCDK8JAK2JAK3 | |
| SCHEMBL29946359 | 0.77 | AURKB (0.57) | PRKCIAXLCDK8JAK2JAK3 | |
| SCHEMBL858198 | 0.77 | AURKB (0.57) | PRKCIAXLCDK8JAK2JAK3 | |
| SCHEMBL28602403 | 0.77 | AXL (0.58) | PRKCIAXLJAK2JAK3JAK1 | |
| SCHEMBL30173287 | 0.77 | AXL (0.58) | PRKCIAXLJAK2JAK3JAK1 | |
| SCHEMBL30173284 | 0.77 | AXL (0.58) | PRKCIAXLJAK2JAK3JAK1 | |
| SCHEMBL3725709 | 0.75 | JAK2 (0.58) | PRKCIAXLCDK8JAK2JAK3 | |
| SCHEMBL30173305 | 0.75 | JAK2 (0.58) | PRKCIAXLCDK8JAK2JAK3 | |
| SCHEMBL30173282 | 0.75 | CLK1 (0.47) | PRKCIAXLCDK8NUDT1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113200983-B | Compound with pyrrolopyridine structure, preparation method and medical application | 中国药科大学 | 2023-01-03 | — | — | CN | disclosed |