Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 2/20 | 0.57 |
| ▸ | IGF1R | P08069 | 2/20 | 0.57 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.57 |
| ▸ | CDK8 | P49336 | 2/20 | 0.57 |
| ▸ | IKBKB | O14920 | 2/20 | 0.57 |
| ▸ | CHUK | O15111 | 2/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | PAK4 | O96013 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.57 |
| ▸ | LTK | P29376 | 1/20 | 0.57 |
| ▸ | GRK5 | P34947 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858198 | 1.00 | AURKB (0.57) | AURKBIGF1RDYRK1BCDK5CDK8 | |
| SCHEMBL12127486 | 0.91 | IGF1R (0.55) | AURKBIGF1RDYRK1BCDK5CDK8 | |
| SCHEMBL12127928 | 0.88 | IKBKB (0.63) | AURKBIGF1RDYRK1BCDK5CDK8 | |
| SCHEMBL1327887 | 0.80 | CDK8 (0.43) | AURKBIGF1RDYRK1BCDK5CDK8 | |
| SCHEMBL2240671 | 0.78 | AURKB (0.71) | AURKBIGF1RDYRK1BCDK5CDK8 | |
| SCHEMBL857022 | 0.77 | CDK8 (0.58) | CDK5CDK8DAPK3PRKD3MAP4K4 | |
| SCHEMBL30173289 | 0.77 | PRKCI (0.50) | AURKBIGF1RDYRK1BCDK5CDK8 | |
| SCHEMBL28603796 | 0.77 | PRKCI (0.50) | AURKBIGF1RDYRK1BCDK5CDK8 | |
| SCHEMBL1719613 | 0.75 | NUDT1 (0.57) | AURKBIGF1RDYRK1BCDK5CDK8 | |
| SCHEMBL13885311 | 0.75 | JAK2 (0.54) | AURKBIGF1RDYRK1BCDK5CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115135659-B | Morpholine derivative, and preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-115135659-A | Morpholine derivatives and preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2022-09-30 | — | — | CN | claimed |
| CN-115135659-B | Morpholine derivative, and preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-115135659-A | Morpholine derivatives and preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2022-09-30 | — | — | CN | disclosed |