Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | XBP1 | P17861 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | GLP1R | P43220 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16709919 | 1.00 | MAPT (0.67) | MAPTALDH1A1TP53TLR9NPSR1 | |
| SCHEMBL9423230 | 0.87 | ALDH1A1 (0.67) | MAPTALDH1A1TP53TLR9NPSR1 | |
| SCHEMBL21678973 | 0.87 | ALDH1A1 (0.51) | MAPTALDH1A1TP53TLR9NPSR1 | |
| SCHEMBL8395110 | 0.85 | ALDH1A1 (0.50) | MAPTALDH1A1TP53TLR9NPSR1 | |
| SCHEMBL21678987 | 0.85 | ALDH1A1 (0.50) | MAPTALDH1A1TP53TLR9NPSR1 | |
| SCHEMBL21679019 | 0.84 | MAPT (0.49) | MAPTALDH1A1TP53TLR9NPSR1 | |
| SCHEMBL29439663 | 0.84 | ALDH1A1 (0.49) | MAPTALDH1A1TP53TLR9NPSR1 | |
| SCHEMBL16505656 | 0.84 | MAPT (0.49) | MAPTALDH1A1TP53TLR9NPSR1 | |
| SCHEMBL2521639 | 0.84 | ALDH1A1 (0.49) | MAPTALDH1A1TP53TLR9NPSR1 | |
| SCHEMBL30667736 | 0.84 | MAPT (0.49) | MAPTALDH1A1TP53TLR9NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697972-B | Receptor-interacting protein 1 inhibitors including piperazine heterocyclic amide urea | 维泰瑞隆有限公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-115697972-A | Receptor-interacting protein 1 inhibitors comprising piperazine heterocyclic amide ureas | 维泰瑞隆有限公司 | 2023-02-03 | — | — | CN | disclosed |