Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 6/20 | 0.40 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25113458 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2HTTKDM4EMAPTGAA | |
| SCHEMBL29353767 | 0.81 | KDM4E (0.46) | KDM4EPTGER1CYP2C9GLS | |
| SCHEMBL21394859 | 0.81 | KDM4E (0.46) | KDM4EPTGER1CYP2C9GLS | |
| SCHEMBL30672289 | 0.79 | GLS (0.42) | GLS | |
| SCHEMBL26822836 | 0.79 | GLS (0.42) | GLS | |
| SCHEMBL30672258 | 0.75 | GLS (0.43) | GLS | |
| SCHEMBL26822131 | 0.75 | GLS (0.43) | GLS | |
| SCHEMBL24824441 | 0.75 | GLS (0.43) | GLS | |
| SCHEMBL13874581 | 0.74 | PTGER1 (0.64) | PTGER1CYP2C9 | |
| SCHEMBL25082075 | 0.74 | GLS (0.54) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250115606-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. | 2025-04-10 | — | — | US | disclosed |
| US-12221442-B2 | Heterocyclic GLP-1 agonists | GASHERBRUM BIO, INC. (US) | 2025-02-11 | — | — | US | disclosed |
| US-20240246962-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. | 2024-07-25 | — | — | US | disclosed |
| US-11926626-B2 | Heterocyclic GLP-1 agonists | GASHERBRUM BIO, INC. (US) | 2024-03-12 | — | — | US | disclosed |
| US-20230107793-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. | 2023-04-06 | — | — | US | disclosed |
| US-20230071840-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. | 2023-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246962-A1 | HETEROCYCLIC GLP-1 AGONISTS | GLP1R, GIPR, GCGR | SMN1; SMN2 1232/4885HTT 819/4885KDM4E 3289/4885 |
| US-12221442-B2 | Heterocyclic GLP-1 agonists | GLP1R, GIPR, GCGR | SMN1; SMN2 1232/4885HTT 819/4885KDM4E 3289/4885 |
| US-20250115606-A1 | HETEROCYCLIC GLP-1 AGONISTS | GLP1R, GIPR, GCGR | SMN1; SMN2 1232/4885HTT 819/4885KDM4E 3289/4885 |
| US-20230071840-A1 | HETEROCYCLIC GLP-1 AGONISTS | GLP1R, GIPR, GCGR | SMN1; SMN2 1232/4885HTT 819/4885KDM4E 3289/4885 |
| US-11926626-B2 | Heterocyclic GLP-1 agonists | GLP1R, GIPR, GCGR | SMN1; SMN2 1232/4885HTT 819/4885KDM4E 3289/4885 |
| US-20230107793-A1 | HETEROCYCLIC GLP-1 AGONISTS | GLP1R, GIPR, GCGR | SMN1; SMN2 1232/4885HTT 819/4885KDM4E 3289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.