Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | ULK1 | O75385 | 3/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25001789 | 0.85 | EGFR (0.69) | EGFRBTKULK1ALKMAP4K1 | |
| SCHEMBL25001385 | 0.85 | EGFR (0.60) | EGFRBTKULK1ALKMAP4K1 | |
| SCHEMBL25001983 | 0.84 | EGFR (0.57) | EGFRBTKULK1LRRK2ALK | |
| SCHEMBL30140980 | 0.83 | EGFR (0.66) | EGFRBTKULK1LRRK2ALK | |
| SCHEMBL25002442 | 0.82 | EGFR (0.54) | EGFRBTKULK1ALKMAP4K1 | |
| SCHEMBL25001489 | 0.81 | EGFR (0.84) | EGFRBTKULK1LRRK2ALK | |
| SCHEMBL30748473 | 0.81 | EGFR (0.68) | EGFRBTKULK1ALKTTK | |
| SCHEMBL25001760 | 0.81 | EGFR (0.68) | EGFRBTKULK1ALKTTK | |
| SCHEMBL25001623 | 0.80 | EGFR (0.64) | EGFRBTKMAP4K1 | |
| SCHEMBL25001487 | 0.80 | EGFR (0.76) | EGFRBTKULK1LRRK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4129996-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | QILU PHARMACEUTICAL CO., LTD. (CN) | 2023-02-08 | — | — | EP | disclosed |