Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | USP14 | P54578 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23886793 | 1.00 | KDM4E (0.33) | KDM4ETSHRLMNAALDH1A1POLB | |
| SCHEMBL26652990 | 0.90 | KDM4E (0.36) | KDM4ETSHRLMNAALDH1A1POLB | |
| SCHEMBL23898401 | 0.89 | KDM4E (0.35) | KDM4ETSHRLMNAALDH1A1POLB | |
| SCHEMBL23886911 | 0.86 | LMNA (0.36) | KDM4ETSHRLMNAALDH1A1POLB | |
| SCHEMBL30176267 | 0.86 | LMNA (0.36) | KDM4ETSHRLMNAALDH1A1POLB | |
| SCHEMBL23886831 | 0.79 | ESR1 (0.34) | KDM4ETSHRLMNAUSP14GAA | |
| SCHEMBL28995439 | 0.79 | KDM4E (0.33) | KDM4ETSHRLMNAPOLBUSP14 | |
| SCHEMBL30176274 | 0.79 | ESR1 (0.34) | KDM4ETSHRLMNAUSP14GAA | |
| SCHEMBL23898683 | 0.78 | AS3MT (0.38) | TSHRLMNAALDH1A1POLB | |
| SCHEMBL23886677 | 0.76 | KDM4E (0.34) | KDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916749-A | Substituted 5-hydroxyindole compounds as alpha-1 antitrypsin modulators | 弗特克斯药品有限公司 | 2023-04-04 | — | — | CN | disclosed |
| EP-4126817-A1 | SUBSTITUTED 5-HYDROXYINDOLE COMPOUNDS AS MODULATORS OF ALPHA-1 ANTITRYPSIN | Vertex Pharmaceuticals Incorporated (US) | 2023-02-08 | — | — | EP | disclosed |